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  1. Semantic features of 'stepped' versus 'continuous' contours in German intonation
    Autor*in: Dombrowski, Ernst
    Erschienen: 2013

  2. Discontinuation of initial antiretroviral therapy in clinical practice: Moving toward individualized therapy
    Autor*in: Di Biagio, Antonio ; Cozzi Lepri, Alessandro ; Prinapori, Roberta ; Angarano, Gioacchino ; Gori, Andrea ; Quirino, Tiziana ; De Luca, Andrea ; Costantini, Andrea ; Mussini, Cristina ; Rizzardini, Giuliano ; Castagna, Antonella ; Antinori, Andrea ; Monforte, Antonella D'arminio ; Moroni, M. ; Andreoni, M. ; Angarano, G. ; Antinori, A. ; D'Arminio Monforte, A. ; Castelli, F. ; Cauda, R. ; Di Perri, G. ; Galli, M. ; Iardino, R. ; Ippolito, G. ; Lazzarin, A. ; Perno, C. F. ; Von Schloesser, F. ; Viale, P. ; Castagna, A. ; Ceccherini Silberstein, F. ; Cozzi Lepri, A. ; Girardi, E. ; Lo Caputo, S. ; Mussini, C. ; Puoti, M. ; Ammassari, A. ; Balotta, C. ; Bandera, A. ; Bonfanti, P. ; Bonora, S. ; Borderi, M. ; Calcagno, A. ; Calza, L. ; Capobianchi, M. R.
    Erschienen: 2016

  3. Prognostic Value of the Fibrosis-4 Index in Human Immunodeficiency Virus Type-1 Infected Patients Initiating Antiretroviral Therapy with or without Hepatitis C Virus
    Autor*in: Mussini, Cristina ; Lorenzini, Patrizia ; Puoti, Massimo ; Lichtner, Miriam ; Lapadula, Giuseppe ; Di Giambenedetto, Simona ; Antinori, Andrea ; Madeddu, Giordano ; Cozzi Lepri, Alessandro ; D'Arminio Monforte, Antonella ; De Luca, Andrea ; Moroni, M. ; Angarano, G. ; Antinori, A. ; D'Arminio Monforte, A. ; Castelli, F. ; Cauda, R. ; Di Perri, G. ; Galli, M. ; Iardino, R. ; Ippolito, G. ; Lazzarin, A. ; Perno, C. F. ; Von Schloesser, F. ; Viale, P. ; Castagna, A. ; Ceccherini Silberstein, F. ; Cozzi Lepri, A. ; Girardi, E. ; Lo Caputo, S. ; Mussini, C. ; Puoti, M. ; Andreoni, M. ; Ammassari, A. ; Balotta, C. ; Bandera, A. ; Bonora, S. ; Borderi, M. ; Calcagno, A. ; Calza, L. ; Capobianchi, M. R. ; Cingolani, A. ; Cinque, P.
    Erschienen: 2015

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  4. The Thessaloniki ESHRE/ESGE consensus on diagnosis of female genital anomalies
    Autor*in: Grimbizis, Grigoris F ; Saravelos, Sotirios H. ; Gordts, Stephan ; Exacoustos, Caterina ; Van Schoubroeck, Dominique ; Bermejo, Carmina ; Amso, Nazar N. ; Nargund, Geeta ; Timmerman, Dirk ; Athanasiadis, Apostolos ; Brucker, Sara ; De Angelis, Carlo ; Gergolet, Marco ; Li, Tin Chiu ; Tanos, Vasilios ; Tarlatzis, Basil ; Farquharson, Roy ; Gianaroli, Luca ; Campo, Rudi ; DI SPIEZIO SARDO, ATTILIO
    Erschienen: 2016

    STUDY QUESTION: What is the recommended diagnostic work-up of female genital anomalies according to the European Society of Human Reproduction and Embryology (ESHRE)/European Society for Gynaecological Endoscopy (ESGE) system? SUMMARY ANSWER: The... mehr

     

    STUDY QUESTION: What is the recommended diagnostic work-up of female genital anomalies according to the European Society of Human Reproduction and Embryology (ESHRE)/European Society for Gynaecological Endoscopy (ESGE) system? SUMMARY ANSWER: The ESHRE/ESGE consensus for the diagnosis of female genital anomalies is presented. WHAT IS KNOWN ALREADY: Accurate diagnosis of congenital anomalies still remains a clinical challenge because of the drawbacks of the previous classification systems and the non-systematic use of diagnostic methods with varying accuracy, some of them quite inaccurate. Currently, a wide range of non-invasive diagnostic procedures are available enriching the opportunity to accurately detect the anatomical status of the female genital tract, as well as a new objective and comprehensive classification system with well-described classes and sub-classes. STUDY DESIGN, SIZE, DURATION: The ESHRE/ESGE CONgenital UTerine Anomalies (CONUTA) Working Group established an initiative with the goal of developing a consensus for the diagnosis of female genital anomalies. The CONUTA working group and imaging experts in the field have been appointed to run the project. PARTICIPANTS/MATERIALS, SETTING, METHODS: The consensus is developed based on: (i) evaluation of the currently available diagnostic methods and, more specifically, of their characteristics with the use of the experts panel consensus method and of their diagnostic accuracy by performing a systematic review of evidence and (ii) consensus for the definition of where and how to measure uterine wall thickness and the recommendations for the diagnostic work-up of female genital anomalies, based on the results of the previous evaluation procedure, with the use of the experts panel consensus method. MAIN RESULTS AND THE ROLE OF CHANCE: Uterine wall thickness is defined as the distance between the interostial line and external uterine profile at the midcoronal plane of the uterus; alternatively, if a coronal plane is not available, the mean anterior and ...

     
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  5. Ultrasonographic evaluation of urethrovesical junction mobility: correlation with type of delivery and stress urinary incontinence
    Autor*in: Cosimato, Cosimo ; Cipullo, Lucio M. A. ; Troisi, Jacopo ; DI SPIEZIO SARDO, ATTILIO ; Tommaselli, Giovanni Antonio ; Oro, Rosa Rita ; Zullo, Fulvio ; Altieri, Vincenzo
    Erschienen: 2015

    A relationship between urinary incontinence and hypermobility of the urethrovesical junction (UVJ) during pregnancy has been described. The aim of the study was to compare the effects of vaginal delivery (VD) and caesarean section (CS) on UVJ... mehr

     

    A relationship between urinary incontinence and hypermobility of the urethrovesical junction (UVJ) during pregnancy has been described. The aim of the study was to compare the effects of vaginal delivery (VD) and caesarean section (CS) on UVJ mobility. The retrovesical angle (RVA) and the anterior angle between the UVJ and the pubic bone, the pubovesical angle (PVA), were evaluated ultrasonographically in controls and pregnant women during their first pregnancy between 38 and 40 weeks, and then re-evaluated 6 weeks and 6 months after delivery. All patients completed a validated questionnaire (ICIQ-SF). Differences between and within groups were assessed with Student's t test, the chi-squared test for trend, and one-way two-tailed analysis of variance with Scheff,'s post-hoc test. The correlation between PVA and RVA was evaluated using the Spearman R correlation. The positive predictive value, negative predictive value, sensitivity and specificity for the prediction of stress urinary incontinence (SUI) symptoms were also determined. Included in the study were 42 controls and 217 pregnant women. PVA at rest, during cough and Valsalva manoeuvre was significantly higher in pregnant women than in controls and in women 6 weeks after VD in comparison with women who had undergone CS. Patients affected by SUI showed a significantly higher PVA. RVA did not differ between subjects affected or not by SUI symptoms. PVA and RVA were not correlated with each other. PVA and RVA are increased in pregnant women in comparison with controls. In patients undergoing VD, PVA is restored significantly later than in those undergoing CS. The change in RVA after pregnancy and delivery seems to persist longer than the change in PVA.

     
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  6. The comprehensiveness of the ESHRE/ESGE classification of female genital tract congenital anomalies: A systematic review of cases not classified by the AFS system
    Autor*in: DI SPIEZIO SARDO, ATTILIO ; Campo, R. ; Gordts, S. ; Spinelli, M. ; Cosimato, C. ; Tanos, V. ; Brucker, S. ; Li, T. C. ; Gergolet, M. ; De Angelis, C. ; Gianaroli, L. ; Grimbizis, G.
    Erschienen: 2015

    STUDY QUESTION How comprehensive is the recently published European Society of Human Reproduction and Embryology (ESHRE)/European Society for Gynaecological Endoscopy (ESGE) classification system of female genital anomalies? SUMMARY ANSWER The... mehr

     

    STUDY QUESTION How comprehensive is the recently published European Society of Human Reproduction and Embryology (ESHRE)/European Society for Gynaecological Endoscopy (ESGE) classification system of female genital anomalies? SUMMARY ANSWER The ESHRE/ESGE classification provides a comprehensive description and categorization of almost all of the currently known anomalies that could not be classified properly with the American Fertility Society (AFS) system. WHAT IS KNOWN ALREADY Until now, the more accepted classification system, namely that of the AFS, is associated with serious limitations in effective categorization of female genital anomalies. Many cases published in the literature could not be properly classified using the AFS system, yet a clear and accurate classification is a prerequisite for treatment. STUDY DESIGN, SIZE AND DURATION The CONUTA (CONgenital UTerine Anomalies) ESHRE/ESGE group conducted a systematic review of the literature to examine if those types of anomalies that could not be properly classified with the AFS system could be effectively classified with the use of the new ESHRE/ESGE system. An electronic literature search through Medline, Embase and Cochrane library was carried out from January 1988 to January 2014. Three participants independently screened, selected articles of potential interest and finally extracted data from all the included studies. Any disagreement was discussed and resolved after consultation with a fourth reviewer and the results were assessed independently and approved by all members of the CONUTA group. PARTICIPANTS/MATERIALS, SETTING, METHODS Among the 143 articles assessed in detail, 120 were finally selected reporting 140 cases that could not properly fit into a specific class of the AFS system. Those 140 cases were clustered in 39 different types of anomalies. MAIN RESULTS AND THE ROLE OF CHANCE The congenital anomaly involved a single organ in 12 (30.8%) out of the 39 types of anomalies, while multiple organs and/or segments of Müllerian ducts (complex ...

     
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  7. Oleic acid content of a meal promotes oleoylethanolamide response and reduces subsequent energy intake in humans
    Autor*in: MENNELLA, ILARIO ; SAVARESE, MARIA ; FERRACANE, ROSALIA ; SACCHI, RAFFAELE ; VITAGLIONE, PAOLA
    Erschienen: 2015

    Animal data suggest that dietary fat composition may influence endocannabinoid (EC) response and dietary behavior. This study tested the hypothesis that fatty acid composition of a meal can influence the short-term response of ECs and subsequent... mehr

     

    Animal data suggest that dietary fat composition may influence endocannabinoid (EC) response and dietary behavior. This study tested the hypothesis that fatty acid composition of a meal can influence the short-term response of ECs and subsequent energy intake in humans. Fifteen volunteers on three occasions were randomly offered a meal containing 30 g of bread and 30 mL of one of three selected oils: sunflower oil (SO), high oleic sunflower oil (HOSO) and virgin olive oil (VOO). Plasma EC concentrations and appetite ratings over 2 h and energy intake over 24 h following the experimental meal were measured. Results showed that after HOSO and VOO consumption the circulating oleoylethanolamide (OEA) was significantly higher than after SO consumption; a concomitantly significant reduction of energy intake was found. For the first time the oleic acid content of a meal was demonstrated to increase the post-prandial response of circulating OEA and to reduce energy intake at subsequent meals in humans.

     
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  8. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention
    Autor*in: Tonino, Pim A. L ; De Bruyne, Bernard ; Pijls, Nico H. J ; Siebert, Uwe ; Ikeno, Fumiaki ; van' t. Veer, Marcel ; Klauss, Volker ; Manoharan, Ganesh ; Engstrøm, Thomas ; Oldroyd, Keith G ; Ver Lee, Peter N ; Maccarthy, Philip A ; Fearon, William F. ; BARBATO, EMANUELE
    Erschienen: 2009

    In patients with multivessel coronary artery disease who are undergoing percutaneous coronary intervention (PCI), coronary angiography is the standard method for guiding the placement of the stent. It is unclear whether routine measurement of... mehr

     

    In patients with multivessel coronary artery disease who are undergoing percutaneous coronary intervention (PCI), coronary angiography is the standard method for guiding the placement of the stent. It is unclear whether routine measurement of fractional flow reserve (FFR; the ratio of maximal blood flow in a stenotic artery to normal maximal flow), in addition to angiography, improves outcomes.

     
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  9. Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake.
    Autor*in: Márquez-Quiñones, Adriana ; Mutch, David, ; Debard, Cyrille ; Wang, Ping ; Combes, Marion ; Roussel, Balbine ; Holst, Claus ; Martinez, J Alfredo ; Handjieva-Darlenska, Teodora ; Kalouskova, Pavla ; Jebb, Susan ; Babalis, Dimitris ; Pfeiffer, Andreas, ; Larsen, Thomas, ; Astrup, Arne ; Saris, Wim, ; Mariman, Edwin ; Clément, Karine ; Vidal, Hubert ; Langin, Dominique ; Viguerie, Nathalie
    Erschienen: 2010
    Verlag:  HAL CCSD ; Oxford University Press

    International audience ; BACKGROUND: The mechanisms underlying body weight evolution after diet-induced weight loss are poorly understood. OBJECTIVE: We aimed to identify and characterize differences in the subcutaneous adipose tissue (SAT)... mehr

     

    International audience ; BACKGROUND: The mechanisms underlying body weight evolution after diet-induced weight loss are poorly understood. OBJECTIVE: We aimed to identify and characterize differences in the subcutaneous adipose tissue (SAT) transcriptome of subjects with different weight changes after energy restriction-induced weight loss during 6 mo on 4 different diets. DESIGN: After an 8-wk low-calorie diet (800 kcal/d), we randomly assigned weight-reduced obese subjects from 8 European countries to receive 4 diets that differed in protein and glycemic index content. In addition to anthropometric and plasma markers, SAT biopsies were taken at the beginning [clinical investigation day (CID) 2] and end (CID3) of the weight follow-up period. Microarray analysis was used to define SAT gene expression profiles at CID2 and CID3 in 22 women with continued weight loss (successful group) and in 22 women with weight regain (unsuccessful group) across the 4 dietary arms. RESULTS: Differences in SAT gene expression patterns between successful and unsuccessful groups were mainly due to weight variations rather than to differences in dietary macronutrient content. An analysis of covariance with total energy intake as a covariate identified 1338 differentially expressed genes. Cellular growth and proliferation, cell death, cellular function, and maintenance were the main biological processes represented in SAT from subjects who regained weight. Mitochondrial oxidative phosphorylation was the major pattern associated with continued weight loss. CONCLUSIONS: The ability to control body weight loss independent of energy intake or diet composition is reflected in the SAT transcriptome. Although cell proliferation may be detrimental, a greater mitochondrial energy gene expression is suggested as being beneficial for weight control. This trial was registered at clinicaltrials.gov as NCT00390637.

     
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