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  1. CB2-63 polymorphism and immune-mediated diseases associated with HCV chronic infection
    Autor*in: Coppola, Nicola ; Zampino, Rosa ; Bellini, Giulia ; Stanzione, Maria ; Capoluongo, Nicolina ; Marrone, Aldo ; Macera, Margherita ; Adinolfi, Luigi Elio ; Giudice, Emanuele Miraglia Del ; Sagnelli, Evangelista ; Rossi, Francesca ; GENTILE, Ivan
    Erschienen: 2016

  2. Prognostic Value of the Fibrosis-4 Index in Human Immunodeficiency Virus Type-1 Infected Patients Initiating Antiretroviral Therapy with or without Hepatitis C Virus
    Autor*in: Mussini, Cristina ; Lorenzini, Patrizia ; Puoti, Massimo ; Lichtner, Miriam ; Lapadula, Giuseppe ; Di Giambenedetto, Simona ; Antinori, Andrea ; Madeddu, Giordano ; Cozzi Lepri, Alessandro ; D'Arminio Monforte, Antonella ; De Luca, Andrea ; Moroni, M. ; Angarano, G. ; Antinori, A. ; D'Arminio Monforte, A. ; Castelli, F. ; Cauda, R. ; Di Perri, G. ; Galli, M. ; Iardino, R. ; Ippolito, G. ; Lazzarin, A. ; Perno, C. F. ; Von Schloesser, F. ; Viale, P. ; Castagna, A. ; Ceccherini Silberstein, F. ; Cozzi Lepri, A. ; Girardi, E. ; Lo Caputo, S. ; Mussini, C. ; Puoti, M. ; Andreoni, M. ; Ammassari, A. ; Balotta, C. ; Bandera, A. ; Bonora, S. ; Borderi, M. ; Calcagno, A. ; Calza, L. ; Capobianchi, M. R. ; Cingolani, A. ; Cinque, P.
    Erschienen: 2015

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  3. Influenza vaccine with adjuvant on disease activity in psoriatic arthritis patients under anti-TNF-Α therapy
    Autor*in: CASO, FRANCESCO ; DEL PUENTE, ANTONIO ; PELUSO, ROSARIO ; SCARPA, RAFFAELE ; COSTA, LUISA ; Ramonda, Roberta ; Darda, Md Abud ; Cantarini, Luca ; Esposito, Carmela ; Ortolan, Augusta ; Fiocco, Ugo ; Punzi, Leonardo
    Erschienen: 2016

    Objective To evaluate the effects on disease activity of seasonal influenza vaccination with adjuvant in psoriatic arthritis (PsA) patients in stable disease activity on anti-TNF-a drugs as compared to not vaccinated PsA patients adequately matched.... mehr

     

    Objective To evaluate the effects on disease activity of seasonal influenza vaccination with adjuvant in psoriatic arthritis (PsA) patients in stable disease activity on anti-TNF-a drugs as compared to not vaccinated PsA patients adequately matched. Methods An observational study was conducted on a cohort of PsA patients in stable disease activity who underwent administration of an adjuvanted vaccine for seasonal influenza. Cases (Group 1) were matched for age, sex, disease activity and therapy with not vaccinated PsA patients (Group 2). Analysis included patients data before vaccination (T0), and one month (T1) and three months (T3) after administration of the vaccination for Group 1 and at correspondent intervals for Group 2. Assessment of disease activity parameters was performed at each visit. Results Twenty-five vaccinated and 25 not vaccinated patients were included in the study. As a first approach, we analysed the data within groups. At T1, as compared to baseline, the group of vaccinated patients had a statistically significant increase in TJC (tender joint count) and ESR (erythrocyte sedimentation rate). At T3, a statistically significant difference from baseline characteristics was found only for the TJC. In Group 2, all the observed variables showed no significant differences when comparing baseline to T1 and T3. Analysis of the data between groups at T1, Group 1, as compared to Group 2, showed a significant increase of TJC, ESR, HAQ (Health Assessment Questionnaire), PtGA (patient global assessment) and PhGA (physician global assessment). These findings were also confirmed when comparing the two groups at T3 for ESR and PtGA, while they were not confirmed for TJC, HAQ and PhGA. Conclusion Influenza vaccination is clinically efficacious in PsA patients under anti-TNF-a therapy, but it could trigger a short-lasting exacerbation of the disease.

     
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    Quelle: BASE Fachausschnitt Germanistik
    Sprache: Englisch
    Medientyp: Aufsatz aus einer Zeitschrift
    Format: Online
    Schlagworte: Adjuvant; Anti-TNF-a therapy; Disease activity; Influenza vaccination; Psoriatic arthriti; Medicine (all)
  4. Psoriatic disease: Clinical staging
    Autor*in: SCARPA, RAFFAELE ; CASO, FRANCESCO ; COSTA, LUISA ; PELUSO, ROSARIO ; Spanò, Angelo ; Lubrano, Ennio ; Del Puente, Antonio ; Moll, John M. H.
    Erschienen: 2015
    Verlag:  Journal of Rheumatology ; country:CAN ; place:;365 Bloor Street East, Suit 901

    In 2006, the introduction of the concept "psoriatic disease" (PsD) extended the traditional idea of a condition confined to skin and joints. Now we consider PsD a systemic condition, in which the increased activity of tumor necrosis factor acts as... mehr

     

    In 2006, the introduction of the concept "psoriatic disease" (PsD) extended the traditional idea of a condition confined to skin and joints. Now we consider PsD a systemic condition, in which the increased activity of tumor necrosis factor acts as the most potent engine for a series of molecular interactions. These lead not only to the genesis of skin and joint symptoms, but also to other clinical aspects such as inflammatory bowel disease, eye involvement, and metabolic syndrome. The blocking of a precise molecular target has dramatically modified therapeutic strategies, making possible adequate control of all the clinical aspects of the condition. Therefore, an expanded clinical staging of patients could now be considered in order to ensure the best therapeutic approach and prognosis.

     
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  5. Adhesions and endometriosis: challenges in subfertility management: (An expert opinion of the ANGEL-The ANti-Adhesions in Gynaecology Expert PaneL-group)
    Autor*in: De Wilde, R. L ; Alvarez, J. ; Brölmann, H. ; Campo, R. ; Cheong, Y. ; Lundorff, P. ; Pawelczyk, L. ; Roman, H. ; Wallwiener, M. ; DI SPIEZIO SARDO, ATTILIO
    Erschienen: 2016

    There is molecular evidence that endometriosis has a negative impact on the ovaries, although the exact pathophysiology concerning endometriosis-associated subfertility is not known. The negative impact on the tubo-ovarian unit can be directly by... mehr

     

    There is molecular evidence that endometriosis has a negative impact on the ovaries, although the exact pathophysiology concerning endometriosis-associated subfertility is not known. The negative impact on the tubo-ovarian unit can be directly by distorting the anatomy, indirectly by invoking inflammation or by oxidative damage with poorer-quality oocytes. Endometriosis even seems to have a negative effect on pregnancy outcome after in vitro fertilization.

     
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    Quelle: BASE Fachausschnitt Germanistik
    Sprache: Englisch
    Medientyp: Aufsatz aus einer Zeitschrift
    Format: Online
    Schlagworte: Adhesion prophylactic agent; Adhesion; Endometriosi; Subfertility management; Medicine (all); Obstetrics and Gynecology
  6. Ultrasonographic evaluation of urethrovesical junction mobility: correlation with type of delivery and stress urinary incontinence
    Autor*in: Cosimato, Cosimo ; Cipullo, Lucio M. A. ; Troisi, Jacopo ; DI SPIEZIO SARDO, ATTILIO ; Tommaselli, Giovanni Antonio ; Oro, Rosa Rita ; Zullo, Fulvio ; Altieri, Vincenzo
    Erschienen: 2015

    A relationship between urinary incontinence and hypermobility of the urethrovesical junction (UVJ) during pregnancy has been described. The aim of the study was to compare the effects of vaginal delivery (VD) and caesarean section (CS) on UVJ... mehr

     

    A relationship between urinary incontinence and hypermobility of the urethrovesical junction (UVJ) during pregnancy has been described. The aim of the study was to compare the effects of vaginal delivery (VD) and caesarean section (CS) on UVJ mobility. The retrovesical angle (RVA) and the anterior angle between the UVJ and the pubic bone, the pubovesical angle (PVA), were evaluated ultrasonographically in controls and pregnant women during their first pregnancy between 38 and 40 weeks, and then re-evaluated 6 weeks and 6 months after delivery. All patients completed a validated questionnaire (ICIQ-SF). Differences between and within groups were assessed with Student's t test, the chi-squared test for trend, and one-way two-tailed analysis of variance with Scheff,'s post-hoc test. The correlation between PVA and RVA was evaluated using the Spearman R correlation. The positive predictive value, negative predictive value, sensitivity and specificity for the prediction of stress urinary incontinence (SUI) symptoms were also determined. Included in the study were 42 controls and 217 pregnant women. PVA at rest, during cough and Valsalva manoeuvre was significantly higher in pregnant women than in controls and in women 6 weeks after VD in comparison with women who had undergone CS. Patients affected by SUI showed a significantly higher PVA. RVA did not differ between subjects affected or not by SUI symptoms. PVA and RVA were not correlated with each other. PVA and RVA are increased in pregnant women in comparison with controls. In patients undergoing VD, PVA is restored significantly later than in those undergoing CS. The change in RVA after pregnancy and delivery seems to persist longer than the change in PVA.

     
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  7. Oleic acid content of a meal promotes oleoylethanolamide response and reduces subsequent energy intake in humans
    Autor*in: MENNELLA, ILARIO ; SAVARESE, MARIA ; FERRACANE, ROSALIA ; SACCHI, RAFFAELE ; VITAGLIONE, PAOLA
    Erschienen: 2015

    Animal data suggest that dietary fat composition may influence endocannabinoid (EC) response and dietary behavior. This study tested the hypothesis that fatty acid composition of a meal can influence the short-term response of ECs and subsequent... mehr

     

    Animal data suggest that dietary fat composition may influence endocannabinoid (EC) response and dietary behavior. This study tested the hypothesis that fatty acid composition of a meal can influence the short-term response of ECs and subsequent energy intake in humans. Fifteen volunteers on three occasions were randomly offered a meal containing 30 g of bread and 30 mL of one of three selected oils: sunflower oil (SO), high oleic sunflower oil (HOSO) and virgin olive oil (VOO). Plasma EC concentrations and appetite ratings over 2 h and energy intake over 24 h following the experimental meal were measured. Results showed that after HOSO and VOO consumption the circulating oleoylethanolamide (OEA) was significantly higher than after SO consumption; a concomitantly significant reduction of energy intake was found. For the first time the oleic acid content of a meal was demonstrated to increase the post-prandial response of circulating OEA and to reduce energy intake at subsequent meals in humans.

     
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  8. SLC26A4 genotypes associated with enlarged vestibular aqueduct malformation in south Italian children with sensorineural hearing loss
    Autor*in: FRANZE', Annamaria ; ESPOSITO, GABRIELLA ; DI DOMENICO, CARMELA ; IOSSA, SANDRA ; Sauchelli, Giuliana ; Fioretti, Tiziana ; CAVALIERE, Michele ; AULETTA, GENNARO ; CORVINO, VIRGINIA ; LARIA, CARLA ; MALESCI, RITA ; MARCIANO, ELIO ; SALVATORE, FRANCESCO
    Erschienen: 2016